ea0086p42 | Endocrine Cancer and Late Effects | SFEBES2022
English Katherine A
, Selberherr Andreas
, Shariq Omair A
, O'Neill Eric
, Lines Kate W
, Thakker Rajesh V
Pancreatic neuroendocrine tumours (PNETs) have a lower mutational burden than other tumours, indicating that other mechanisms contribute to tumourigenesis. One such reported mechanism is DNA methylome dysregulation, however, inconsistencies have been observed between gene methylation and protein expression, potentially stemming from the use of standard methylation assessment methods which do not distinguish methylation (5methylcytosine (5mC), repressive mark) from ...